239101-33-8

239101-33-8 structure

Name: Deferitrin
Chemical Name: (2Z,4S)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-1,3-thiazolidine-4-carboxylic acid
CAS Number: 239101-33-8
Molecular Formula: C₁₁H₁₁NO₄S
Molecular Weight: 253.274
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-01-20 18:47:05
Modify Date: 2025-08-25 23:17:40
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].

Name	(2Z,4S)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-1,3-thiazolidine-4-carboxylic acid
Synonyms	(4S)-2-(2,4-Dihydroxyphenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid 4'-Hydroxydesazadesferrithiocin GT 56-252 4-Thiazolecarboxylic acid, 2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-, (4S)- UNII-T69Y9LDN44 Deferitrin

Description	Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%[1].
References	[1]. Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51(13):3913-23. [2]. Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4.

Density	1.5±0.1 g/cm3
Boiling Point	525.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₁NO₄S
Molecular Weight	253.274
Flash Point	271.8±32.9 °C
Exact Mass	253.040878
PSA	115.42000
LogP	-0.13
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.683

64419-24-5

76045-30-2

239101-33-8

Literature: Bergeron, Raymond J.; Wiegand, Jan; McManis, James S.; McCosar, Bruce H.; Weimar, William R.; Brittenham, Gary M.; Smith, Richard E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 13 p. 2432 - 2440

627101-38-6

~15%

239101-33-8

Literature: Genzyme Corporation Patent: US2003/220504 A1, 2003 ; Location in patent: Page/Page column 3-4 ;

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