THP-PEG4-Pyrrolidine(N-Me)-CH2OH

Names

[ CAS No. ]:
2378261-81-3

[ Name ]:
THP-PEG4-Pyrrolidine(N-Me)-CH2OH

Biological Activity

[Description]:

THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H37NO7

[ Molecular Weight ]:
391.50

[ Storage condition ]:
-20°C

Related Compounds