THP-PEG4-Pyrrolidine(N-Me)-CH2OH
Names
[ CAS No. ]:
2378261-81-3
[ Name ]:
THP-PEG4-Pyrrolidine(N-Me)-CH2OH
Biological Activity
[Description]:
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].
[Related Catalog]:
[Target]
PEGs
[In Vitro]
PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H37NO7
[ Molecular Weight ]:
391.50
[ Storage condition ]:
-20°C