DCN1-UBC12-IN-2

Names

[ Name ]:
DCN1-UBC12-IN-2

Biological Activity

[Description]:

DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[In Vitro]

DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 27.34 μM for 24 h.

[References]

[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₀ClN₇O₃S₂

[ Molecular Weight ]:
542.03

Related Compounds

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