2374827-47-9

2374827-47-9 structure

Name: DCN1-UBC12-IN-2
Chemical Name: DCN1-UBC12-IN-2
CAS Number: 2374827-47-9
Molecular Formula: C₂₃H₂₀ClN₇O₃S₂
Molecular Weight: 542.03
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2022-04-27 19:30:05
Modify Date: 2024-01-10 20:30:06
DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].

Name	DCN1-UBC12-IN-2

Description	DCN1-UBC12-IN-2 is a potent and specific DCN1-UBC12 inhibitor (IC50=9.55 nM). DCN1-UBC12-IN-2 could specifically target DCN1-UBC12 interaction and relieve Ang II-induced cardiac fibroblast activation[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
In Vitro	DCN1-UBC12-IN-2 (DN-2) possesses relatively low cytotoxicity toward cardiac fibroblasts (CFs) with an IC50 of 27.34 μM for 24 h.
References	[1]. He ZX, et al. Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects. J Med Chem. 2022;65(1):163-190.

Molecular Formula	C₂₃H₂₀ClN₇O₃S₂
Molecular Weight	542.03