J-1048

Names

[ CAS No. ]:
2374772-60-6

[ Name ]:
J-1048

Biological Activity

[Description]:

J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[References]

[1]. Yang HX, et al. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation. Bioorg Chem. 2023 Oct;139:106723.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H17FN6S2

[ Molecular Weight ]:
460.55