CMLD012073

Names

[ Name ]:
CMLD012073

Biological Activity

[Description]:

CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 against NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

eIF4A[1]

[In Vitro]

In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1].

[References]

[1]. Chu J, et al. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 Nov 21;26(11):1586-1593.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₀N₂O₇

[ Molecular Weight ]:
530.57

Related Compounds

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