Desmorpholinyl Navitoclax-NH-Me

Names

[ Name ]:
Desmorpholinyl Navitoclax-NH-Me

Biological Activity

[Description]:

Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557)[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[References]

[1]. Guangrong Zheng, et al. Agents de dégradation de protéines bcl-2 pour le traitement du cancer. WO2019144117A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₅₁ClF₃N₅O₅S₃

[ Molecular Weight ]:
918.55

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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