CRBN-6-5-5-VHL

Names

[ Name ]:
CRBN-6-5-5-VHL

Biological Activity

[Description]:

CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

[Target]

Cereblon:1.5 nM (DC50)

[References]

[1]. Christian Steinebach, et al. PROTAC-mediated crosstalk between E3 ligases. Chem Commun (Camb). 2019 Feb 5;55(12):1821-1824.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₆₉N₇O₁₀S

[ Molecular Weight ]:
972.20

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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