T01-1

Names

[ CAS No. ]:
2356229-14-4

[ Name ]:
T01-1

Biological Activity

[Description]:

T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1]. Cell Proliferation Assay[1] Cell Line: HCC1806 cells Concentration: 0-50 nM Incubation Time: 3 days Result: Inhibited cell proliferation with an EC50 value of 6.7 nM.

[In Vivo]

T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1]. Animal Model: Sprague Dawley rat (half male and half female)[1]. Dosage: 1 mg/kg Administration: Intravenous injection; single Result: 1.19Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1]. IV (1 mg/kg) Female Male AUCLast (ng/mL•h) 437 214 Cmax (ng/mL) 838 625 MRTINF (h) 2.81 0.44 T1/2 (h) 2.78 1.97 Tmax (h) 0.08 0.08

[References]

[1]. Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₉N₃O₆S

[ Molecular Weight ]:
511.59

Related Compounds

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