2356229-14-4
2356229-14-4 structure
- Name: T01-1
- Chemical Name: T01-1
- CAS Number: 2356229-14-4
- Molecular Formula: C26H29N3O6S
- Molecular Weight: 511.59
- Catalog: Research Areas Cancer
- Create Date: 2022-11-21 19:50:39
- Modify Date: 2024-04-03 20:12:51
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T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].
| Name | T01-1 |
|---|
| Description | T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1]. Cell Proliferation Assay[1] Cell Line: HCC1806 cells Concentration: 0-50 nM Incubation Time: 3 days Result: Inhibited cell proliferation with an EC50 value of 6.7 nM. |
| In Vivo | T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1]. Animal Model: Sprague Dawley rat (half male and half female)[1]. Dosage: 1 mg/kg Administration: Intravenous injection; single Result: 1.19Pharmacokinetic Parameters of T01-1 in Sprague Dawley rat [1]. IV (1 mg/kg) Female Male AUCLast (ng/mL•h) 437 214 Cmax (ng/mL) 838 625 MRTINF (h) 2.81 0.44 T1/2 (h) 2.78 1.97 Tmax (h) 0.08 0.08 |
| References |
| Molecular Formula | C26H29N3O6S |
|---|---|
| Molecular Weight | 511.59 |