Paltimatrectinib

Names

[ Name ]:
Paltimatrectinib

Biological Activity

[Description]:

Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[Target]

TrkA

[References]

[1]. Kollol Pal, et al. 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer. WO2019118584A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅F₅N₆

[ Molecular Weight ]:
434.37

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.