dMCL1-2

Names

[ Name ]:
dMCL1-2

Biological Activity

[Description]:

dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

[Target]

KD: 30 nM (MCL1)[1]

[References]

[1]. Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.

Chemical & Physical Properties

[ Density]:
1.43±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₆₁H₆₆N₁₀O₁₂S

[ Molecular Weight ]:
1163.30

Related Compounds

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