2351218-88-5

2351218-88-5 structure

Name: dMCL1-2
Chemical Name: dMCL1-2
CAS Number: 2351218-88-5
Molecular Formula: C₆₁H₆₆N₁₀O₁₂S
Molecular Weight: 1163.30
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-08-03 21:04:59
Modify Date: 2025-08-26 18:22:02
dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1].

Name	dMCL1-2

Description	dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	KD: 30 nM (MCL1)[1]
References	[1]. Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.