Peimine

Names

[ Name ]:
Peimine

[Synonym ]:
Peimine
Isodihydroimperialin
5α-Cevane-3β,6α,20-triol
verticine
(3β,5α,6α)-Cevane-3,6,20-triol
Verticine,Zhebeinine,Wanpeinine A
ISODIHYDROIMPERIALINE
Dihydroisoimperialine
(3b,5a,6a)-cevane-3,6,20-triol
cevane-3,6,20-triol, (3b,5a,6a)-
Cevane-3,6,20-triol, (3β,5α,6α)-

Biological Activity

[Description]:

Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Inflammation/Immunology

[References]

[1]. Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
568.4±50.0 °C at 760 mmHg

[ Melting Point ]:
233-234ºC

[ Molecular Formula ]:
C₂₇H₄₅NO₃

[ Molecular Weight ]:
431.651

[ Flash Point ]:
275.3±28.8 °C

[ Exact Mass ]:
431.339935

[ PSA ]:
63.93000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.