Irisolidone

Names

[ Name ]:
Irisolidone

[Synonym ]:
Irisolidone
4',6-dimethoxy-5,7-dihydroxyisoflavone
5,7-dihydroxy-6,4'-dimethoxyisoflavone
4'-O-Methyltectorigenin
4'-methoxytectorigenin

Biological Activity

[Description]:

Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Neurological Disease

[In Vitro]

Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC50 of 9.8 μM in HEK293 cells[3]. Irisolidone can inhibit endothelial cell proliferation[3].

[References]

[1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8.

[2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9.

[3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483.

Chemical & Physical Properties

[ Density]:
1.402g/cm3

[ Boiling Point ]:
565.5ºC at 760mmHg

[ Melting Point ]:
192 ºC (methanol )

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.28900

[ Flash Point ]:
212.3ºC

[ Exact Mass ]:
314.07900

[ PSA ]:
89.13000

[ LogP ]:
2.88840

[ Vapour Pressure ]:
2.15E-13mmHg at 25°C

[ Index of Refraction ]:
1.645

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Practically insoluble (0.05 g/L) (25 ºC)

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%