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(S,R,S)-AHPC-C8-NH2 dihydrochloride

Names

[ CAS No. ]:
2341796-80-1

[ Name ]:
(S,R,S)-AHPC-C8-NH2 dihydrochloride

Biological Activity

[Description]:

(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. [1].Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H49Cl2N5O4S

[ Molecular Weight ]:
658.72

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds