(S,R,S)-AHPC-C2-NH2 dihydrochloride

Names

[ Name ]:
(S,R,S)-AHPC-C2-NH2 dihydrochloride

Biological Activity

[Description]:

(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. WO2020038415A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₇Cl₂N₅O₄S

[ Molecular Weight ]:
574.56

Safety Information

[ Hazard Codes ]:
Xi

(S,R,S)-AHPC-C2-NH2 dihydrochloride

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds