2(1H)-Pyridinone,4-hydroxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-

Names

[ Name ]:
2(1H)-Pyridinone,4-hydroxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-

[Synonym ]:
3-hydroxypropyl 2-thienyl ketone
3-Deazauridin-2',3',5'-tribenzoat

Biological Activity

[Description]:

4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
709.4ºC at 760mmHg

[ Molecular Formula ]:
C₃₁H₂₅NO₉

[ Molecular Weight ]:
555.53

[ Flash Point ]:
382.8ºC

[ Exact Mass ]:
555.15300

[ PSA ]:
130.36000

[ LogP ]:
3.75950

[ Vapour Pressure ]:
4.03E-21mmHg at 25°C

[ Index of Refraction ]:
1.67

2(1H)-Pyridinone,4-hydroxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream