TD-165
Names
[ CAS No. ]:
2305936-56-3
[ Name ]:
TD-165
Biological Activity
[Description]:
TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].
[Related Catalog]:
[Target]
Cereblon:20.4 nM (DC50)
[In Vitro]
TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1]. TD-165 (0.1-10 μM; 24 hours) lead to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1]. Cell Viability Assay[1] Cell Line: HEK293T cells Concentration: 0-100 nM Incubation Time: 24 hours Result: Exhibited an DC50 value of 20.4 nM. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.1, 1, and 10 μM Incubation Time: 24 hours Result: Decreased the level of CRBN protein.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C46H59N7O8S
[ Molecular Weight ]:
870.07
Safety Information
[ Hazard Codes ]:
Xi