BRD7-IN-1 free base

Names

[ CAS No. ]:
2305379-66-0

[ Name ]:
BRD7-IN-1 free base

Biological Activity

[Description]:

BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD7, BRD9[1]


[References]

[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H26N4O3

[ Molecular Weight ]:
394.47

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds