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Pomalidomide-C2-NH2 hydrochloride

Names

[ CAS No. ]:
2305369-00-8

[ Name ]:
Pomalidomide-C2-NH2 hydrochloride

Biological Activity

[Description]:

E3 ligase Ligand 17 hydrochloride is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[References]

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H17ClN4O4

[ Molecular Weight ]:
352.77

Related Compounds