Exatecan intermediate 9

Names

[ CAS No. ]:
2290562-59-1

[ Name ]:
Exatecan intermediate 9

Biological Activity

[Description]:

Exatecan intermediate 9 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H24FN3O5

[ Molecular Weight ]:
477.48

Related Compounds

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