ABBV-467

Names

[ Name ]:
ABBV-467

Biological Activity

[Description]:

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

MCL-1[1].

[References]

[1]. Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₅₁Cl₂FN₆O₉S

[ Molecular Weight ]:
1037.98

Related Compounds

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