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CEM114

Names

[ CAS No. ]:
2279062-54-1

[ Name ]:
CEM114

Biological Activity

[Description]:

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CRISPR/Cas9
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[In Vitro]

CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1]. Cell Viability Assay[1] Cell Line: HEK 293T cells Concentration: 200 nM Incubation Time: 48 hours Result: Significantly activated the GFP signal.

[References]

[1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C84H122FN9O19S

[ Molecular Weight ]:
1612.98

Related Compounds