MDL-811

Names

[ Name ]:
MDL-811

Biological Activity

[Description]:

MDL-811, an allosteric SIRT6 activator, significantly activates SIRT6 histone H3 deacetylation (H3K9Ac, H3K18Ac, and H3K56Ac). MDL-811 could be used in the study of colorectal cancer[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[References]

[1]. Jialin Shang, et al. Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D3 in colorectal cancer. Theranostics. 2020 Apr 27;10(13):5845-5864.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅BrCl₂FN₃O₅S₂

[ Molecular Weight ]:
681.42

Related Compounds

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