<Suppliers Price>

Isocryptotanshinone

Names

[ CAS No. ]:
22550-15-8

[ Name ]:
Isocryptotanshinone

[Synonym ]:
4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione

Biological Activity

[Description]:

Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer

[Target]

STAT3

PTP1B:56.1 μM (IC50)


[In Vitro]

It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].

[References]

[1]. Guo S, et al. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Dec;24(10):934-942.

[2]. Han YM, et al. PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull. 2005 Sep;28(9):1795-7.


[Related Small Molecules]

SHP099 hydrochloride | Tyrphostin B42 (AG-490) | Stattic | AS1517499 | S3I-201 | LB-100 | Salubrinal | Cryptotanshinone | Calyculin A | Napabucasin | Homoharringtonine | STAT5-IN-1 | WP1066 | SF1670 | Stibogluconate sodium

Chemical & Physical Properties

[ Molecular Formula ]:
C19H20O3

[ Molecular Weight ]:
296.36000

[ Exact Mass ]:
296.14100

[ PSA ]:
43.37000

[ LogP ]:
3.59990

Safety Information

[ Hazard Codes ]:
Xi