Isecarosmab

Names

[ Name ]:
Isecarosmab

Biological Activity

[Description]:

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Isecarosmab 结合 ADAMTS-5，但不结合 ADAMTS-1、ADAMTS-4 和 ADAMTS-15[1]。 Isecarosmab (1-100 nM，5 天) 在受到促炎刺激的牛和 OA 人软骨外植体中降低 huARGS、exAGNxI 和 GAG 水平[1]。 Isecarosmab (24-72 h) 阻断 ADAMTS-5 介导的 DCS TLR2 激活[2]。

[In Vivo]

Isecarosmab (0.1-10 mg/kg，皮下注射，每三天一次) 减轻内侧半月板 (DMM) 切除小鼠的内侧软骨退化[1]。

[References]

[1]. Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21(17):5992.

[2]. Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28(5):658-668.

[3]. C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495). 2018. 26 (1), S299-S300.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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