2254082-79-4
2254082-79-4 structure
- Name: Isecarosmab
- Chemical Name: Isecarosmab
- CAS Number: 2254082-79-4
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2023-04-02 18:31:56
- Modify Date: 2024-04-09 18:32:08
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Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].
| Name | Isecarosmab |
|---|
| Description | Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3]. |
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| Related Catalog | |
| In Vitro | Isecarosmab 结合 ADAMTS-5，但不结合 ADAMTS-1、ADAMTS-4 和 ADAMTS-15[1]。 Isecarosmab (1-100 nM，5 天) 在受到促炎刺激的牛和 OA 人软骨外植体中降低 huARGS、exAGNxI 和 GAG 水平[1]。 Isecarosmab (24-72 h) 阻断 ADAMTS-5 介导的 DCS TLR2 激活[2]。 |
| In Vivo | Isecarosmab (0.1-10 mg/kg，皮下注射，每三天一次) 减轻内侧半月板 (DMM) 切除小鼠的内侧软骨退化[1]。 |
| References |
| No Any Chemical & Physical Properties |