Tecaginlimab

Names

[ CAS No. ]:
2253891-70-0

[ Name ]:
Tecaginlimab

Biological Activity

[Description]:

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

CD40

4-1BB


[In Vitro]

Tecaginlimab 结合重组人 CD40 和 4-1BB，亲和力分别为 1.0 nM 和 0.17 nM[1]。 Tecaginlimab (0.001-1 µg/mL; 5 d) 在体外诱导树突状细胞 (DC) 成熟[1]。 Tecaginlimab (0.2 µg/mL; 10-15 d) 在体外增强 T 细胞活化[1]。

[In Vivo]

Tecaginlimab (0.0008-0.2 µg/mL; 4 d) 增强肿瘤浸润淋巴细胞的扩增[1]。

[References]

[1]. Muik A, et, al. DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity. J Immunother Cancer. 2022 Jun;10(6):e004322.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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