2253891-70-0
2253891-70-0 structure
- Name: Tecaginlimab
- Chemical Name: Tecaginlimab
- CAS Number: 2253891-70-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-26 07:10:09
- Modify Date: 2024-01-13 16:38:37
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Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1].
| Name | Tecaginlimab |
|---|
| Description | Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1]. |
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| Related Catalog | |
| Target |
CD40 4-1BB |
| In Vitro | Tecaginlimab 结合重组人 CD40 和 4-1BB，亲和力分别为 1.0 nM 和 0.17 nM[1]。 Tecaginlimab (0.001-1 µg/mL; 5 d) 在体外诱导树突状细胞 (DC) 成熟[1]。 Tecaginlimab (0.2 µg/mL; 10-15 d) 在体外增强 T 细胞活化[1]。 |
| In Vivo | Tecaginlimab (0.0008-0.2 µg/mL; 4 d) 增强肿瘤浸润淋巴细胞的扩增[1]。 |
| References |
| No Any Chemical & Physical Properties |