Dooku 1

Names

[ Name ]:
Dooku 1

[Synonym ]:
MFCD32174346

Biological Activity

[Description]:

Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel. Dooku1 inhibited 2 μM Yoda1-induced Ca2+-entry with IC50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₉Cl₂N₃OS

[ Molecular Weight ]:
326.20

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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