GSK9311 hydrochloride

Names

[ Name ]:
GSK9311 hydrochloride

Biological Activity

[Description]:

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRPF1:6.0 (pIC50)

BRPF2:4.3 (pIC50)

[In Vitro]

GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].

[References]

[1]. Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂ClN₅O₃

[ Molecular Weight ]:
474.00

GSK9311 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds