2253733-09-2

2253733-09-2 structure

Name: GSK9311 hydrochloride
Chemical Name: GSK9311 hydrochloride
CAS Number: 2253733-09-2
Molecular Formula: C₂₄H₃₂ClN₅O₃
Molecular Weight: 474.00
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-06-01 18:41:43
Modify Date: 2024-01-12 00:37:27
GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

Name	GSK9311 hydrochloride

Description	GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRPF1:6.0 (pIC50) BRPF2:4.3 (pIC50)
In Vitro	GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].
References	[1]. Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7.

Molecular Formula	C₂₄H₃₂ClN₅O₃
Molecular Weight	474.00