Clozic

Names

[ Name ]:
Clozic

[Synonym ]:
Clobuzaritum [INN-Latin]
Clobuzarit
EINECS 245-035-4
2-[[p-(p-chlorophenyl)benzyl]oxy]-2-methylpropionic acid
2-((4'-Chloro-4-biphenylyl)methoxy)-2-methylpropionic acid
Clobuzaritum
2-{[(4'-chlorobiphenyl-4-yl)methyl]oxy}-2-methylpropanoic acid
Propanoic acid,2-((4'-chloro(1,1'-biphenyl)-4-yl)methoxy)-2-methyl
2-[4-(4-chlorophenyl)benzyloxy]-2-methylpropionic acid
Clozic

Biological Activity

[Description]:

Clozic is a potential anti-arthritic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1].

[Cell Assay]

Approximately 3×104 to 5×104 cells/mL medium are seeded into 24-well plates and incubated at 37°C in a humidified atmosphere of 95% air/5% CO2. Medium is replaced with fresh medium containing 20% foetal calf serum and methanol or Clozic under investigation. Cell numbers are determined in replicate wells on various days during culture growth[1].

[References]

[1]. Foster SJ, et al. Anti-proliferative properties of Clozic, a disease-modifying anti-arthritic agent. Biochem Pharmacol. 1983 Feb 1;32(3):461-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
472ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₇ClO₃

[ Molecular Weight ]:
304.76800

[ Flash Point ]:
239.2ºC

[ Exact Mass ]:
304.08700

[ PSA ]:
46.53000

[ LogP ]:
4.38680

[ Vapour Pressure ]:
1.03E-09mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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