DI-591
Names
[ CAS No. ]:
2245887-38-9
[ Name ]:
DI-591
Biological Activity
[Description]:
DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells.
[References]
References 1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150. View Related Products by Target Ubiquitin-conjugating Enzyme (E2)
Chemical & Physical Properties
[ Molecular Formula ]:
C31H47N5O4S
[ Molecular Weight ]:
585.808
Related Compounds
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