2245887-38-9
2245887-38-9 structure
- Name: DI-591
- Chemical Name: DI-591
- CAS Number: 2245887-38-9
- Molecular Formula: C31H47N5O4S
- Molecular Weight: 585.808
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2020-01-11 13:20:29
- Modify Date: 2025-08-25 19:07:52
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DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells.
| Name | DI-591 |
|---|
| Description | DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2; displays no affinity against DCN3/4/5 (Ki>10 uM); selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members; accumulates NRF2 protein and its transcriptional activation in cells. |
|---|---|
| References | References 1. Zhou H, et al. Nat Commun. 2017 Oct 27;8(1):1150. View Related Products by Target Ubiquitin-conjugating Enzyme (E2) |
| Molecular Formula | C31H47N5O4S |
|---|---|
| Molecular Weight | 585.808 |