DW14800

Names

[ Name ]:
DW14800

Biological Activity

[Description]:

DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

PRMT5[1]

[References]

[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₆N₄O₃

[ Molecular Weight ]:
512.64

Related Compounds

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