2243709-60-4

2243709-60-4 structure

Name: DW14800
Chemical Name: DW14800
CAS Number: 2243709-60-4
Molecular Formula: C₃₁H₃₆N₄O₃
Molecular Weight: 512.64
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2019-06-30 16:08:15
Modify Date: 2024-01-09 22:34:14
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].

Name	DW14800

Description	DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	PRMT5[1]
References	[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.

Molecular Formula	C₃₁H₃₆N₄O₃
Molecular Weight	512.64