Depemokimab

Names

[ Name ]:
Depemokimab

Biological Activity

[Description]:

Depemokimab (GSK-3511294) is a long-acting anti-IL-15 monoclonal antibody. Depemokimab can be used for research of asthma[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[Target]

IL-15[1]

[In Vivo]

Depemokimab (食蟹猴药代动力实验) 与 Mepolizumab (HY-P9945) 相比，清除率降低约 2 倍，IL-5 结合亲和力比 Mepolizumab 高约 30 倍[2]。

[References]

[1]. Calzetta L, et al. Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma. Biomedicines. 2022 Sep 19;10(9):2330.

[2]. Singh D, et al. A Phase 1 study of the long-acting anti-IL-5 monoclonal antibody GSK3511294 in patients with asthma. Br J Clin Pharmacol. 2022 Feb;88(2):702-712.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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