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BAY 2416964

Names

[ CAS No. ]:
2242464-44-2

[ Name ]:
BAY 2416964

Biological Activity

[Description]:

AHR antagonist 3 is a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compound and an aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. AHR antagonist 3 has anti-cancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

[Target]

IC50: 341 nM (Aryl hydrocarbon receptor (AHR))[1]


[In Vitro]

AHR antagonist 3 (Example 192) induces AHR-regulated gene CYP1A1 expression in a human monocytic U937 cells with an IC50 of 4.3 nM[1].

[References]

[1]. Ilona GUTCHER, et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1

Chemical & Physical Properties

[ Density]:
1.42±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C18H18ClN5O3

[ Molecular Weight ]:
387.82

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds