FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2

Names

[ CAS No. ]:
2241669-84-9

[ Name ]:
FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2

Biological Activity

[Description]:

FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 is a linker of AUTAC4. AUTAC4 contains an p-fluorobenzylguanine (FBnG) and a phenylindole moiety, which can induce K63-linked polyubiquitination and degradation of mitochondria in HeLa cells[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Takahashi D, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H39FN8O6S

[ Molecular Weight ]:
622.71

Related Compounds

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