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PKCiota-IN-2

Names

[ CAS No. ]:
2230055-52-2

[ Name ]:
PKCiota-IN-2

Biological Activity

[Description]:

PKCiota-IN-2 is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCι:2.8 nM (IC50)

PKCα:71 nM (IC50)

PKCε:350 nM (IC50)


[References]

[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21N5O

[ Molecular Weight ]:
395.46

Related Compounds

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