Avizakimab

Names

[ CAS No. ]:
2229685-51-0

[ Name ]:
Avizakimab

Biological Activity

[Description]:

Avizakimab (BOS161721) is a humanized IgG1 monoclonal antibody that targets interleukin-21[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[In Vitro]

Avizakimab (BOS161721) 可阻止 IL-21 与 IL-21 受体 (IL-21R) 结合，并抑制生物活性[1]。 Avizakimab 可抑制 IL-21 诱导的下游信号传导、浆细胞分化和自然杀伤细胞激活，并抑制抗体对匙孔戚血蓝蛋白 (keyhole limpet hemocyanin; KLH) 抗原的反应[1]。

[References]

[1]. Hussaini A, et al. A Double-Blind, Phase I, Single Ascending Dose Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BOS161721 in Healthy Subjects. Clin Transl Sci. 2020 Mar;13(2):337-344.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.