BRP-201

Names

[ Name ]:
BRP-201

Biological Activity

[Description]:

Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the treatment of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

[Target]

mPGES-1:0.42 μM (IC50)

[References]

[1]. Ergül AG, et al. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₇ClN₄OS

[ Molecular Weight ]:
503.06

BRP-201

Names

Biological Activity

Chemical & Physical Properties

Related Compounds