2227434-74-2

2227434-74-2 structure

Name: BRP-201
Chemical Name: BRP-201
CAS Number: 2227434-74-2
Molecular Formula: C₂₈H₂₇ClN₄OS
Molecular Weight: 503.06
Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
Create Date: 2022-03-24 09:50:36
Modify Date: 2024-01-10 21:30:26
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the treatment of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.

Name	BRP-201

Description	Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the treatment of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> PGE synthase
Target	mPGES-1:0.42 μM (IC50)
References	[1]. Ergül AG, et al. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167.

Molecular Formula	C₂₈H₂₇ClN₄OS
Molecular Weight	503.06