Ga(III) protoporphyrin IX

Names

[ Name ]:
Ga(III) protoporphyrin IX

Biological Activity

[Description]:

Ga(III)protoporphyrin-IX is a model for the key interporphyrin interactions in malaria pigment. Ga(III)protoporphyrin-IX acts as a potent antibacterial against gram-negative, gram-positive, and acid-fast bacteria. Ga(III)protoporphyrin-IX is readily soluble in methanol (MeOH). Ga(III)protoporphyrin IX are as malarial pigment analogues for drug development and as potential antibacterial agents[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Ga(III)protoporphyrin-IX has also been shown to bind to heme containing proteins and enzymes when it is included in the cellular growth medium of the Grampositive bacteria Enterococcus faecalis which does not depend on heme for cell growth. Ga(III)protoporphyrin-IX has shown to be a suitable mimic of heme and has potential applications in heme replacement/substitution[1].

[References]

[1]. Pinter TB, et al. Spectroscopic and theoretical studies of Ga(III)protoporphyrin-IX and its reactions with myoglobin. Inorg Chem. 2012;51(6):3743-3753.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₁GaN₄O₄

[ Molecular Weight ]:
629.36

Related Compounds

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