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LOXO-292

Names

[ CAS No. ]:
2222755-14-6

[ Name ]:
LOXO-292

[Synonym ]:
LOXO-292

Biological Activity

[Description]:

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 1 nM (RETWT), 7 nM (RETV804M), 101 nM (RETG810R)


[References]

[1]. Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H31N9O3

[ Molecular Weight ]:
553.61

[ Storage condition ]:
2-8℃

Related Compounds