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Selpercatinib (LOXO-292)

Names

[ CAS No. ]:
2152628-33-4

[ Name ]:
Selpercatinib (LOXO-292)

Biological Activity

[Description]:

Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 14.0 nM (RETWT), 24.1 nM (RETV804M), 530.7 nM (RETG810R)[1]


[References]

[1]. Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

[2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 32, No. 4, 2018.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H31N7O3

[ Molecular Weight ]:
525.60

Related Compounds