Bm-MPK1-IN-15b

Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM; inhibits human p38α and JNK3 with IC50 of 26 and 170 nM, respectively; reduces the motility of adult worms at 100 nM, Bm-MPK1-IN-15b is a tool compound for in vivo studies aimed at strengthening the role of Bm MPK1 in B. malayi response to host oxidative stress.

References 1. Tummalapalli SR, et al. ACS Med Chem Lett. 2018 Feb 9;9(3):210-214. View Related Products by Target Parasite